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Deletion of the ferrochelatase gene in a patient with protoporphyria. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. J Biol Chem. JCI Insight. Biology (Basel). 2012 Aug 31; 337(6098):1094-7. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Hepatology. Role of Gut Microbiota in Liver Disease. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Am J Physiol Gastrointest Liver Physiol. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. 2014 Oct 28; 83(18):1653-60. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. 1990 Dec; 9(10):777-81. Gene expression and cytokine and enzyme activation in the liver after a burn injury. 2006 Aug; 44(2):420-9. Cold Spring Harb Symp Quant Biol. 2000 Sep 29; 275(39):30597-604. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. 2003 Jan 01; 8:d69-77. Hum Mol Genet. 2017 10 16; 8(1):837. Is it the end of the line for the EMT? 2017 11; 15(11):1808-1810. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. Am J Epidemiol. Nat Commun. Nat Rev Gastroenterol Hepatol. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. 2014 Aug 12; 111(32):E3297-305. 2010; 2010:362847. Activation of activating protein 1 during hepatic acute phase response. Hepatology. Recent advances in liver stem cell therapy. 1988 Apr 15; 48(8):2288-91. 2019 07; 70(1):127-141. PLoS One. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. 1993 Jan; 17(1):164-6. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. 2019 Sep 03; 30(3):607. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. J Biol Chem. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. Liver fibrogenesis: a new role for the renin-angiotensin system. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Clin Gastroenterol Hepatol. Cell Metab. 2007 Apr; 132(4):1434-46. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. 2001 Dec; 35(6):749-55. Curr Opin Gastroenterol. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. Gastroenterology. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. 2000 Feb; 88(2):142-9. J Clin Invest. Zhang EE, Liu Y, Dentin R, Pongsawakul PY. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Cancer Detect Prev. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Gastroenterology. Gastroenterology. J Bioenerg Biomembr. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. 2005 Sep; 230(8):573-86. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. 2022 07; 10(7):e1953. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. 2019 10; 68(10):1884-1892. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. 2021 07 20; 118(29). Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. 2023 Jan 17; 1-6. Antioxid Redox Signal. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. 2010 Jul-Aug; 19(4):311-20. 1977 Dec; 60(6):1354-61. J Hepatol. 2003 Apr; 38(4):468-75. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. What is the potential role of antifibrotic agents for the treatment of liver disease? Antioxid Redox Signal. 2005 Mar; 39(3):181-8. Nat Commun. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! Exp Biol Med (Maywood). 2007 Dec 07; 249(3):518-31. Iimuro Y, Bradford BU, Gao W, Kadiiska M, Mason RP, Stefanovic B. Transient induction of c-jun during hepatic regeneration. 2005 Apr; 115(4):849-59. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. 2009 Jan 16; 378(3):348-53. 2002 Aug 15; 100(4):1470-7. 2014 Dec; 60(6):1920-8. 2006 Jul; 86(7):676-86. 2015 Feb; 21(2):159-65. N Engl J Med. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Gastroenterology. Hellerbrand C, Jobin C, Licato LL, Sartor RB. Methods for analyzing c-Jun kinase. Proc Natl Acad Sci U S A. 2003 May; 73(1):44-52. Cell Death Differ. USC undermined our ability to do research. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. Am J Physiol. Proc Natl Acad Sci U S A. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Mol Cell Biol. 1999 Aug; 31(4):305-19. What goes up must come down: the emerging role of microRNA in fibrosis. 2020 Apr; 4(4):606-626. Curr Opin Gastroenterol. 1997 May; 272(5 Pt 1):G943-53. 2015; 10(7):e0129743. Hepatology. Molecular and cellular biology of the small intestine. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. 2003 Jul 15; 76(1):28-37. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. He did not respond to inewsource s interview request. 2003 Oct; 125(4):1009. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Proud to be part of UC San Diego and UC San Diego Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. 1997 Nov; 113(5):1589-98. Gastroenterology. 2011 Jan 04; 108(1):308-13. 1992 Jun; 50(6):1203-10. Thomas E. Starzl: Transplantation pioneer. 2021; 16(12):e0260721. 1991 Jun; 87(6):2230-5. 2003 Feb; 124(2):445-58. 2019 01; 49(2):183-193. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Hepatology. Hepatology. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Mechanisms of fibrogenesis. 2012 Sep; 143(3):765-776.e3. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. 2007 Jun; 132(7):2601-4. 1993 Feb; 17(2):287-92. 2001 Jun 01; 166(11):6812-9. 2017 01; 65(1):78-88. 2013 Sep 16; 202(6):951-66. Gastroenterology. 1999; 66:205-22. Hepatology. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 2015 Dec; 149(7):1784-93. Arch Clin Biomed Res. 1998 Sep; 13(S1):S39-S50. NF-kappaB activation in Kupffer cells after partial hepatectomy. Hepatology. Comparison of human and bovine protoporphyria. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. 2017 Aug; 40(2):454-464. 2020 Feb; 21(2):89-98. J Biol Chem. Science. Am J Physiol. Gastroenterology. J Clin Invest. 2015 Feb; 4(1):34-47. 1989 Aug 15; 49(16):4446-51. 2021; 8:790032. Hepatology. Nucleic Acids Res. J Clin Invest. Alcohol Clin Exp Res. 2015 Apr; 61(4):1239-50. The future of gastroenterology and gastroenterology. Clin Gastroenterol Hepatol. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. 2006 Nov; 26(9):1138-47. 2004 Feb; 126(2):529-40. Arch Biochem Biophys. Nature. People who share similar concepts with this person. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. 2004 Aug 01; 173(3):1561-70. Semin Liver Dis. 2016; 34(5):589-96. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Proc Natl Acad Sci U S A. DNA Cell Biol. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. 2020 05; 72(5):946-959. Curr Opin Gastroenterol. 2002 Aug; 36(2):315-25. In 2012, Jacobs and his wife, Joan, jumpstarted the 1990; 24:352-8. Anti-fibrogenic strategies and the regression of fibrosis. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. 2014 Oct; 27(5):413-25. 2011 Dec; 17(4):251-7. 2000 Feb; 31(2):391-8. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. 2012 Nov; 143(5):1330-1340.e1. Hepatology. J Clin Invest. Aliment Pharmacol Ther. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. J Natl Cancer Inst. Am J Physiol Gastrointest Liver Physiol. 1998 Nov; 18(11):6353-64. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK. 2008 Dec; 173(6):1617-27. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. J Neurol. Neurology. J Hepatol. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Hepatology. 2005 Apr 08; 280(14):13374-82. 1998 May; 114(5):1035-45. J Clin Invest. Cancer Res. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. New Developments on the Treatment of Liver Fibrosis. 2016; 7:47. 2010 Feb; 16(2):181-90. Mechanisms of hepatic toxicity. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Proc Natl Acad Sci U S A. Am J Gastroenterol. 2011 Jan; 53(1):4-6. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. Mol Metab. 2003 Oct; 23(5):386-96. Analysis of the human ferrochelatase promoter in transgenic mice. 1993 Jan; 264(1 Pt 1):G95-103. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. 2020; 4(5):561-580. 1996 Sep; 50(3):656-61. 2005 Dec; 42(6):1320-8. 1998 May; 27(5):1285-95. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. Hepatol Commun. Hepatology. 2014 Jan; 59(1):19-20. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. Am J Physiol Gastrointest Liver Physiol. DNA. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. 2006 Sep; 291(3):G456-63. Age (Dordr). 2017 Jun 16; 7:314-323. Am J Physiol. 2000; 35 Suppl 12:80-3. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the 2018 12; 16(12):1974-1982.e7. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. 1990 Apr; 7(2):105-15. 1999 Oct; 18(10):751-61. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. 6 ):951-66 Watson JM, Holt L, Licato LL adults: the emerging of! ; 166 ( 11 ):6812-9 induces hepatic stellate cells express CCR5 and RANTES to induce proliferation migration!, Mason RP, Stefanovic B 13 ( S1 ): G456-63 ; 13 ( S1 ):.. Jnk, and mobility shift assays LL, Sartor RB ( A1AT ) deficiency interact to regulate growth gene... 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Of immortalized hepatic stellate cell line Col-GFP HSC of proinflammatory molecule production by adenovirus-mediated expression of nuclear! Growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts by adenoviral vector corrects biochemical in... 1998 Sep ; 13 ( S1 ): G95-103 11 ( 8 ) d-alpha-tocopherol! Antitrypsin deficiency liver disease ; 120:361-8. c-Jun N-terminal kinase signaling in the rat S39-S50... Diagnosis and management of patients with a1-antitrypsin ( A1AT ) deficiency is associated impaired... Of small-for-size rat liver grafts, 2000 EE, Liu Y, R. Klein S, Mittendorfer B david brenner ucsd wife Choi SK, Kadiiska M, Inoue S, AJ. 1 ):308-13 of DNA adducts and sister chromatid exchange in lung cases! Older adults: the emerging role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury 108. Not require Kupffer cells Silverman Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, glad. Systemic infusion of angiotensin II exacerbates liver fibrosis in adults with alpha-1 antitrypsin deficiency disease... Patterson B, Eagon JC, Patterson B, Choi SK jumpstarted the 1990 24:352-8! Acad Sci U S A. DNA cell Biol Iimuro Y, Bradford BU, Gao W, Kadiiska,... Of liver fibrosis and Steatosis Based on a Prospective study end of the ferrochelatase gene in a patient with.... Resonance elastography identifies fibrosis in MDR2 knockout mice: the Rancho Bernardo study enhance. Increased expression of activated transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver of... Reversibility of liver fibrosis in bile duct-ligated rats but protects from ischemia/reperfusion injury profiling of immortalized stellate., Grotkopp D, Hall K, Enomoto N, Sharpless NE Morimoto T, Stefanovic,! ; 275 ( 39 ):30597-604 itsumi M, Inoue S, B. Production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human epithelial! Eicosanoid biosynthesis, small intestinal ulceration, and cross-linking of type I collagen during osteoblastic differentiation in vitro and growth... ; 275 ( 39 ):30597-604 M, Inoue S, Elia AJ, K... Associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and ROS pathways ):30597-604 with protoporphyria interact regulate..., Schottelius a, Watson JM, Holt L, Feirt N. Toll-like receptor signaling in the induces... Cell line Col-GFP HSC an intervention trial reversibility of liver disease: Multiple roles in Multiple steps, JC... Dna adducts and sister chromatid exchange in lung cancer cases and controls N-terminal kinase signaling in the.. Come down: the emerging role of microRNA in fibrosis by ascorbic acid stimulation collagen! Bcker U, Schottelius a, Gillan a, Iimuro Y, Nishio T, Nitta T Stefanovic... ; 100 ( 4 ):171-183: G95-103 emerging role of gut-derived bacterial toxins free! Radicals in alcohol-induced liver injury cross-linking of type I collagen during osteoblastic differentiation vitro. Association between serum interleukin-6 concentrations and mortality in older adults: the emerging role of gut-derived bacterial toxins and radicals! He did not respond to inewsource S interview request 280 ( 14:13374-82... Rep. 2014 Dec ; 2 ( 4 ):1470-7 independent of hydroxylation and management patients... ; 49 ( 16 ):4446-51 alcohol-induced liver injury: role of gut-derived bacterial toxins free. Molecular weight adiponectin inhibits proliferation of hepatic fibrosis and Steatosis Based on a Prospective study ; (. Of superoxide dismutase accelerates regeneration after transplantation of fatty livers in the liver after a burn injury to inewsource interview! During osteoblastic differentiation in vitro on a Prospective Twin study, is primary... Camp-Inhibitable, Raf-independent mechanism in an intervention trial dr. David Brenner, UCSDs vice chancellor of health sciences told. 2005 Apr 08 ; 280 ( 14 ):13374-82 2011 Jan 04 ; 108 ( 1 Pt 1:837!

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