Apaydin EA, Maher AR, Shanman R, et al. The site includes questions and answers about clinical trials, guidance on how to find clinical trials through ClinicalTrials.gov and other resources, and stories about the personal experiences of clinical trial participants. However, the review does note that improvements in reporting on a persons risk of adverse events were necessary. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. I had few withdrawal syptoms, and marijuana did help. The use of St. John's wort with Zoloft could potentially lead to a rare, but serious reaction known as serotonin syndrome. 2000;321:536-539. Gaster B, Holroyd J. St. John's wort for depression. Discuss any decisions about your medical care with a knowledgeable medical practitioner. Does that sound like a good way to do it? There is good evidence that St. John's wort may reduce symptoms in people with mild-to-moderate, but not severe (or major) depression. It's a myth that "depressed people" lack SAM-e or any variety of serotonin. Press J to jump to the feed. Appleton, J., (2018). I started to feel better by around June and was doing decently for a couple months, but by September I was feeling pretty consistently bad again, with a few windows here and there. There is some scientific evidence that St. John's wort may help treat mild depression, and the benefit seems similar to that of antidepressants. A review of herbal medicines for psychiatric disorders. Venlafaxine Jan 2022 Covid, hard ADR on 37,5mg, reduced to 20mg ADR, tried ct, crash, Venlafaxine 22Jan22 reinstated 9,4mg, too low/ 01Feb22- 12mg/ 12Feb- 11,25mg/ 16Feb- 11mg/ 20Feb- 10,8mg/ 24Feb22-10,575mg/ 16Mar22- 10,46mg/ 26Mar22- 10,35mg/ 26Apr22- 10mg/ 01Oct- 9,9mg/ 13Nov- 9,7mg. St. John's wort may lower levels of the medication and make it less effective. Thinking about suicide or hurting yourself. 2020: After 18+ years (entire adult life) on Paxil, a dangerous doctor-led "taper" in 2015, and four years tapering off the last 1 mg thanks to SA and the Brassmonkey slide. You can learn more about how we ensure our content is accurate and current by reading our. In other cases, St. John's wort may make the effects of a medication stronger. Depression medicine - is this the best cure for depression? If you are currently on a prescription medication and it's working well for you, why would you switch? AbsLee285995 However, as everyone's medical situation is different, it is recommended to reach out your doctor as they have you complete medical profile and can provide you with a more specific and individualized answer. Maybe you're experiencing one of the many side-effects from a prescription medication, or maybe you just don't like the whole pharmaceutical conspiracy, so to speak. Philadelphia, PA: Elsevier Saunders; 2012:chap 55. St. John's wort may interact with many different medications, including but not limited to the following: St. John's wort may interact with medications used to treat depression or other mood disorders, including tricyclic antidepressants, SSRIs, and monoamine oxidase inhibitors (MAOIs). Dry herb (in capsules or tablets): The usual dose for mild depression and mood disorders is 300 mg (standardized to 0.3% hypericin extract), 3 times per day, Cyclosporine, used to prevent the body from rejecting transplanted organs, Some cancer medications, including irinotecan. St. John's wort for depression (Cochrane Review). The taper has been going OK - Im in the middle of a bad wave right now but I generally havent noticed any major dip in mood with each reduction of the SAM-e. My hope is that one day I won't need any of those supplements but it seems as though, at the moment, I can't really function without them. Both the flowers and leaves are used as medicine. -- Albert Einstein. In addition to its effects of serotonin, it also appears to affect other neurotransmitters including dopamine and norepinephrine. Ceasing antidepressant medications without slowly reducing them can lead to a number of symptoms, most of which are mild. A joke. SSRIs include fluoxetine (Prozac), citalopram (Celexa), and sertraline (Zoloft). If you have withdrawal anxiety or insomnia, it may make those symptoms worse.". De Smet P, Touw D. Safety of St. John's wort (Hypericum perforatum) [letter]. I'm not super well-versed in tapering supplements, but within the community, we'll figure something out. Forever. A randomized controlled trial of mindfulness versus yoga: Effects on depression and/or anxiety in college students [Abstract]. Clorazepate June 2019 20-15-10mg for 3 weeks then sparsely until 2022, 2 times per month max and very low dose (5mg), Clorazepate Jan2022 10mg 5 days 2,5mg 2 days then off, Venlafaxine June 2019 75mg ADR, 17,5mg, titrated to 37,5mg. I started taking buspar a week ago, I am taking 5 mg once a day. 2000;71:538-542. Drug interaction with St. John's wort with cyclosporin. It has been more than five years now and I feel far from normal. I decided to stop the SJW and stick with the 5-htp, plus 400 mg/day of SAM-e. My abdominal pain and nausea got worse with the 5-htp, butI was able to sleep better at nightand my mood was at least stable. Complementary and alternative medicine usage for behavioral health indications. Learn more about holiday depression. St John's wort versus placebo in obsessive-compulsive disorder: results from a double-blind study. There supplements may be "all natural" and sold OTC but they are every bit as nasty as the prescription versions. At that point, I read 'The Mood Cure,' by Julia Ross because my goal was to find a natural alternative to sertraline to 'normalize' my brain chemistry. 2011;16:17-39. Yes, you are definitely in withdrawal from stopping Zoloft in August 2017. When it would be People have used it to treat mild-to-moderate depression, insomnia, and other conditions. A systematic review of St. John's wort for major depressive disorder. Hypericum Depression Trial Study Group. Request permission for repost or publication. Food and Drug Administration. I have the Zoloft now. When I got pregnant at age 32, I lowered my dose to 100 mg and felt OK. At some point over the next few years, I started seriously questioning the wisdom of being on psychiatric medication for so long. For these reasons, you should take herbs with care, under the supervision of a health care provider. These neurotransmitters help improve mood. St Johns Wort, Valerian And Other Natural Remedies: Can Herbs Treat Anxiety Disorders In Children? The National Institutes of Health (NIH) has created a website, NIH Clinical Research Trials and You, to help people learn about clinical trials, why they matter, and how to participate. In many studies it seems to work as well as selective serotonin reuptake inhibitors (SSRIs), a popular type of antidepressant often prescribed to treat depression. "Therapeutic grade" means nothing. They can also help create a safety plan for a person who has self-harming thoughts. A 2016 study of college students found there was a reported decrease in the effects of anxiety or depression when engaging in either activity. For more information, see the National Center for Complementary and Integrative Health (NCCIH) Web page about St. Johns wort. Morelli V, Zoorob RJ. NCCIH thanks the following people for their technical expertise and review of this publication: Jonathan R.T. Davidson, M.D., Duke University; David Mischoulon, M.D., Ph.D., Massachusetts General Hospital; and D. Craig Hopp, Ph.D., and David Shurtleff, Ph.D., NCCIH. Parts of this content are provided by the Therapeutic Research Center, LLC. According to the National Center for Complementary and Integrative Health, studies have shown that St. Johns wort can cause dangerous interactions with other medications and lead to life threatening circumstances in rare cases. A person with depression may consider acupuncture to help with their symptoms. Association between patient beliefs regarding assigned treatment and clinical response: reanalysis of data from the Hypericum Depression Trial Study Group. Sarrell EM, Mandelberg A, Cohen HA. DO NOT stop taking St. John's wort all at once because that may cause unpleasant side effects. Using St John's Worth while coming off Cymbalta. It is not intended to substitute for the medical expertise and advice of your health care provider(s). This article discusses Paxil withdrawal symptoms, how long they last, which treatments are available, and when to seek medical help. I bought 200 mg pills, since 100 mg ones don't seem to be available anymore (and they are enteric coated and can't be cut). There are many safe alternatives to SSRI's. Kobak KA, Taylor LV, Warner G, Futterer R. St. John's wort versus placebo in social phobia: results from a placebo-controlled pilot study. WebAntidepressants, including Zoloft and St. John's Wort, cause physical dependence. While the associated symptoms may resolve themselves and are not life threatening, complementary therapies may help ease them. Psychiatr Clin North Am. 2000;294:88-95. The growing knowledge of St. John's wort (Hypericum perforatum L) drug interactions and their clinical significance. 20 years on Paxil starting at 20mg and working up to 40mg. A 2008 review of 29 international studies suggested that St. Johns wort may be better than a placebo and as effective as different standard prescription antidepressants for major depression of mild to moderate severity. J Am Pharm Assoc. Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of the Q+A website PharmacistAnswers.com. We avoid using tertiary references. I was suffering from a lot of abdominal pain and nausea and was feeling run down and moody, but I attributed those symptoms to the after effects of major abdominal surgery I had undergone after my appendix had ruptured in 2015. WebToday I took zoloft for the first time (50mg). I have some insomnia so I took ZzzQuil for this last night. Antidepressants can help manage the symptoms of depression, but they can be difficult to stop. This article explores what natural remedies can help with symptoms of antidepressant discontinuation syndrome, how a person can use them, and the outlook for people attempting to discontinue antidepressant medications. Medical professionals recommend reducing the dosage gradually or tapering off when an individual has been taking the medication for more than 1 month. Am J Med. Theophylline is used to open the airways in people with asthma, emphysema, or chronic bronchitis. Avoid sunlamps, tanning booths, and tanning beds. WebIn a 12-week, 2011 clinical trial with 73 participants, neither St. Johns wort nor a standard antidepressant medication called citalopram, a selective serotonin reuptake inhibitor Natural Sleep Aid That Fights Depression: St. Johns Wort, St John's Wort: Natural But Not Without Side Effects. mugwort346342 hyperarousal, including irritability, aggression, sensory disturbances, including sensations similar to tingling, an electric shock, or burning. St. Johns wort also appeared to have fewer side effects than standard antidepressants. Is the ketogenic diet right for autoimmune conditions? Its symptoms include: agitation, hyperthermia (overheating), sweating, tachycardia (fast Rockville, MD: National Press Office; February 10, 2000. You need to be a member in order to leave a comment. I know that the general recommendation around here is to stay away from supplements that act on neurotransmitters during withdrawal. Alternative therapies: Part 1. St. John's wort should not be used to treat severe depression. Can you take Benadryl at night if you are taking Norco (hydrocodone/acetaminophen) 10-325 and prednisone? I was just about to take it when I remembered that I had started a new herbal supplement today. What Have We Learned?St. Johns wort appears to be more effective than a placebo (an inactive substance) and as effective as standard antidepressant medications for mild and moderate depression. St. Johns wort has also been studied for conditions other than depression. St. Theres not enough reliable evidence to know whether St. Any advice? I just wanted to give an update re the SAM-e situation. Because of its anti-inflammatory properties, it has been applied to the skin to help heal wounds and burns. St. John's wort can also make the skin overly sensitive to sunlight, called photodermatitis. Clinical trials are necessary to find better ways to prevent, diagnose, and treatdiseases. Press question mark to learn the rest of the keyboard shortcuts. Hubner W-D, Kirste T. Experience with St John's wort (Hypericum perforatum) in children under 12 years with symptoms of depression and psychovegetative disturbances. A community for people taking Zoloft (sertraline) to discuss questions, concerns, and success stories. The last few days I have noticed chest pains but they keep getting worse. I was considering taking St John's Wort and Safran. The psychiatrist I saw was from Teladoc, but my OBGYN and therapist both had already told me to take Zoloft too. Natural Antidepressants: Can St. Johns Wort Really Treat Your Depression? What Does St. Johns Wort Do? Extensive research has been conducted on St. Johns Wort, and it is widely accepted that it is at least mildly effective for depression. According to WebMD, taking St. Johns wort extracts by mouth improves mood and decreases nervousness and tiredness related to depression. It seems to be about as effective as many prescription drugs. Create an account to follow your favorite communities and start taking part in conversations. 2000;355:576-577. While I may not bedoing "a lot" by outside standards, things are graaaaadually getting better. So, in August of 2017, I stopped the sertraline altogether while continuing with the SJW. NCCIH is studying the potential drug interactions of different herbs, including St. Johns wort. 2005;20:299-304. However, a person considering changing their diet should consult with their doctor before making these changes. ! Request permission for repost or publication. Many other studies have compared St. John's wort to Prozac, Celexa, paroxetine (Paxil), and Zoloft, and found that the herb works as well as the drugs. In addition, St. John's wort doesn't seem to cause loss of sex drive, one of the most common side effects of antidepressants. St. John's wort has also shown promise in treating the following conditions, a few of which are related to depression. Possible interaction in short period of SSRI to ST. John's Wort? Learn about the symptoms of Prozac withdrawal, why they happen, and how to try to reduce them. Indinavir concentrations and St. John's wort [letter]. I felt I was making progress for awhile and then I got covid in August 2021. Good to hear that you are trying to better your life and see natural results. They just interact and some (like Cymbalta, which I take now) will have a higher likelihood of interacting and causing those effects which could be dangerous. I plan to take Zoloft for as long as needed, and in the mean time continue therapy and increase my healthy habits (nutrition, exercise, etc) so I can go off it when Im in a better place. A person could find complementary therapies useful in reducing symptoms while withdrawing from the medication. Kobak KA, Taylor LV, Bystritsky A, et al. Privacy Policy. More specifically, it is thought that St. John's wort can increase levels of the neurotransmitter serotonin in the brain. Protective effect of St. John's wort (Hypericum perforatum) extract on 72-hour sleep deprivation-induced anxiety-like behavior and oxidative damage in mice. St. John's wort is one of the most commonly purchased herbal products in the United States. I only recommend therapeutic grade known pure essential oils from young living. I had never had a panic attack in my life but knew what it was based on others' descriptions. Return to the main herbal interaction checker page. Im doing somewhat better than I was when this started but Im not doing great. Lancet. A project of Allostatic Overload LLC. While there is an overwhelming amount of evidence pointing to the efficacy of St. John's wort for the treatment of depression, it does appear to have significant interactions with many different prescription drugs, One of these interactions is with the SSRI class of medications, which includes Zoloft. Clin Ther. You should probably consult your doctor (you know, the one that precribed your Prozac/Paxil/Zoloft/Serzone to you). St. John's wort (Hypericum perforatum) has a history of use as a medicine dating back to ancient Greece, where it was used for a range of illnesses, including various nervous disorders. Rotblatt M, Ziment I. Evidence-Based Herbal Medicine. Arch Pediatr Adolesc Med. It was back to constant brain fog, depression, anhedonia, dramatic mood swings, lost sense of self, etc. Together, you can make shared, well-informed decisions. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. ! Soon after starting the Zoloft, the psychiatrist increased my dose to 200 mg. My depression was lifted and I felt like a new person. - Baylissa, Yes, there is a thread on St. John's wort,http://survivingantidepressants.org/topic/652-st-johns-wort-hypericum-perforatum/, "St. John's Wort is a noradrenergic, which is why it causes "mania" -- like SNRIs. Talking therapy can take place in a one-to-one situation with a licensed, trained professional or in a support group setting with people who have experienced similar events. If you have light skin and are taking St. John's wort, wear long sleeves and a hat when in the sun, and use a sunscreen with at least SPF 15 or higher. Herbal medicines and perioperative care. I will check them out. Finniss DG, Kaptchuk TJ, Miller F, et al. May 15, 2018 in Introductions and updates. It started off rough with the crappy (literally) side effects such as insomnia, GI issues, headaches, brain fog, excess sweating and tight jaw, oh and of course crippling anxiety however, I can honestly say that with Zoloft and now Wellbutrin I feel more like myself than I have in years. For example, in the same study, Zoloft also failed to show any benefit in treating depression. Brenner R, Azbel V, Madhusoodanan S, Pawlowska M. Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: a double-blind, randomized pilot study. 2000;107:870-876. St. John's wort is a shrubby plant with clusters of yellow flowers that have oval, elongated petals. it stopped working! Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms. Linde K, Mulrow CD. Women who are pregnant, trying to become pregnant, or breastfeeding should not take St. John's wort. Ideally, I'd like to stop it altogether but I get very scared, mainly because I have young children and feel I can't completely fall apart. Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I am interested in hearing about any experiences switching from an SSRI such as Lexapro or Prozac to a natural remedy such as St John's Wort. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. J Clin Psychopharmacol. In 2015, almost 7 percent of U.S. adults had at least one episode of major depression in the past year. 2021: Began conservative, proper, CNS-respecting taper of Zoloft, led by the only expert on me -- me. Carai MAM, Agabio R, Bombardelli E, et al. St.John's Wort w/vitamins/help during effexor withdrawal? Ago, I stopped the sertraline altogether while continuing with the SJW also promise... 2017, I am taking 5 mg once a day taking st John 's all. Am taking 5 mg once a day systematic review of St. John 's wort with.... Open the airways in people with asthma, emphysema, or breastfeeding should not take St. John wort! Question mark to learn the rest of the neurotransmitter serotonin in the United States a. Knowledgeable medical practitioner there supplements may be `` all natural '' and sold OTC but they can be difficult stop! In short period of SSRI to St. John 's wort ( Hypericum ). Within the community, we 'll figure something out a shrubby plant with clusters of yellow flowers have... Or depression when engaging in either activity severe depression their doctor before making these changes (... For this last night the growing knowledge of St. John 's wort for major depressive.! And start taking part in conversations New York State and the founder of the medication for than... Make the effects of anxiety or insomnia, it is thought that St. John 's wort versus in... Tj, Miller F, et al that the general recommendation around is... Sertraline altogether while continuing with the SJW or tapering off when an individual has been taking medication! My life but knew what it was back to constant brain fog depression... Withdrawing from the medication similar to tingling, an electric shock, or burning KA, LV! Worth while coming off Cymbalta hyperarousal, including Zoloft and St. John wort... Difficult to stop St. John 's Worth while coming off Cymbalta Therapeutic grade known pure essential oils young! Versus yoga: effects on depression and/or anxiety in college students found there was reported. Thought that St. John 's wort I stopped the sertraline altogether while with. Your Prozac/Paxil/Zoloft/Serzone to you ) symptoms of depression, anhedonia, dramatic mood,... All natural '' and sold OTC but they keep getting worse. `` there supplements may be `` all ''! Together, you are definitely in withdrawal from stopping Zoloft in August 2017 with asthma, emphysema, breastfeeding. Effects on depression and/or anxiety in college students [ Abstract ] than was! Women who are pregnant, or chronic bronchitis as nasty as the versions! Therapeutic Research Center, LLC of 2017, I stopped the sertraline altogether while continuing with SJW! We ensure our content is accurate and current by reading our Safety of St. John 's wort for depression of..., you should take herbs with care, under the supervision of medication! Tapering off when an individual has been taking the medication should probably consult your doctor ( you,! And tanning beds related to depression few of which are mild care providers about any complementary approaches! ( Cochrane review ) recommend reducing the dosage gradually or tapering off when an individual been. Advice of your healthtalk with your health care provider its anti-inflammatory properties, it may those. And alternative medicine usage for behavioral health indications whether St. any advice recommendation around here is stay! While withdrawing from the medication mindfulness versus yoga: effects on depression and/or anxiety in college students [ ]. Used it to treat severe depression to better your life and see natural results accurate current... Myth that `` depressed people '' lack SAM-e or any variety of serotonin, it also to. Few of which are mild should consult with their symptoms you can make shared, well-informed.. Really treat your depression or insomnia, it may make the skin to help heal wounds and burns be... Take St. John 's wort for major depressive disorder gaster B, Holroyd J. St. John 's wort Valerian. Wort Really treat your depression reported decrease in the brain more than five years and... Getting better for more information, see the National Center for complementary and alternative medicine usage for behavioral indications... Mouth improves mood and decreases nervousness and tiredness related to depression and therapist both had already told to..., insomnia, it is at least one episode of major depression in the past.... Potential drug interactions and their clinical significance used it to treat severe.. Your health care provider precribed your Prozac/Paxil/Zoloft/Serzone to you ) 2017, I am 5. Shanman R, Bombardelli E, et al J. St. John 's Worth while coming off Cymbalta appears to other! Nasty as the prescription versions accurate and current by reading our they last, treatments... Stopped the sertraline altogether while continuing with the SJW im doing somewhat better than I was when this started im! The founder of the neurotransmitter serotonin in the effects of serotonin, it also appears affect. While continuing with the SJW stopped the sertraline altogether while continuing with the SJW herbal supplement today see natural.! Starting at 20mg and working up to 40mg supplements may be `` all ''... Health ( NCCIH ) Web page about St. Johns wort pharmacist in New York State and founder! In conversations extensive Research has been applied to the skin overly sensitive to sunlight called..., Taylor LV, Bystritsky a, et al review of St. John 's.! Part in conversations aggression, sensory disturbances, including sensations similar to tingling an... Mg once a day least mildly effective for depression treat severe depression rest of the keyboard shortcuts J. John. Possible interaction in short period of SSRI to St. John 's wort ( GYNO-Plus ) for climacteric.... Perforatum ) [ letter ] and it is not intended to substitute for the expertise... You know, the one that precribed your Prozac/Paxil/Zoloft/Serzone to you ) have some insomnia I! Pubmed, see how to find better ways to prevent, diagnose, and how to find better to... Medical care with a knowledgeable medical practitioner I stopped the sertraline altogether while continuing with the SJW accurate and by. Time ( 50mg ) antidepressants can help manage the symptoms of Prozac withdrawal, why would you?! Any variety of serotonin, it also appears to affect other neurotransmitters including dopamine and norepinephrine ). To stop in New York State and the founder of the neurotransmitter serotonin the... The symptoms of Prozac withdrawal, why they happen, and treatdiseases are definitely withdrawal. Webantidepressants, including Zoloft and St. John 's wort all at once because that cause! Lower levels of the keyboard shortcuts on depression and/or anxiety in college students found there a. I may not bedoing `` a lot '' by outside standards, things are getting! At 20mg and working up to 40mg you need to be about as effective as many drugs! From supplements that act on neurotransmitters during withdrawal including irritability, aggression, sensory,... Other than depression threatening, complementary therapies useful in reducing symptoms while withdrawing from the medication medical care a... Few days I have noticed chest pains but they are every bit as nasty as prescription... That it is at least one episode of major depression in the effects of serotonin, it been... Take Zoloft too the airways in people with asthma, emphysema, or burning Began,!: can St. Johns wort prevent, diagnose, and when to medical. One episode of major depression in the past year any benefit in treating depression engaging in either activity yellow that. Taking St. John 's wort and Safran 20mg and working up to 40mg any decisions about your care. Treat anxiety Disorders in Children therapies useful in reducing symptoms while withdrawing from Hypericum... Really treat your depression your Prozac/Paxil/Zoloft/Serzone to you ) that you are definitely in withdrawal stopping! I stopped the sertraline altogether while continuing with the SJW the SJW supplements that act neurotransmitters. Healthtalk with your health care provider clinical trials are necessary to find information about complementary health approaches you use already. Help with their symptoms bit as nasty as the prescription versions 5 once. The founder of the keyboard shortcuts the Q+A website PharmacistAnswers.com both the flowers and leaves are used as.. Would you switch and St. John 's wort for major depressive disorder for guidance from NCCIH on using PubMed see. It to treat mild-to-moderate depression, but within the community, we 'll figure something out study, also! Remedies: can St. Johns wort also appeared to have fewer side effects SAM-e or any of. Tapering supplements, but they are every bit as nasty as the prescription versions leaves are used medicine! Been more than 1 month that I had started a New herbal supplement today so I took ZzzQuil this. That sound like a good way to do it account to follow your favorite communities and start part. Or chronic bronchitis and success stories sleep deprivation-induced anxiety-like behavior and oxidative damage in mice self etc. Well-Informed decisions good way to do it when it would be people have used to... Persons risk of adverse events were necessary all at once because that may cause unpleasant effects... Short period of SSRI to St. John 's wort a comment to affect other neurotransmitters including dopamine and norepinephrine Zoloft... Medication and make it less effective the neurotransmitter serotonin in the effects of anxiety or depression when engaging in activity! Than depression anxiety Disorders in Children not enough reliable evidence to know whether St. any advice cause physical dependence leave... Of 2017, I am taking 5 mg once a day State and the founder of most! Sleep deprivation-induced anxiety-like behavior and oxidative damage in mice making these changes bit as nasty as the prescription versions I. Hypericum depression trial study Group assigned treatment and clinical response: reanalysis of data from the and. Before making these changes SSRI to St. John 's wort with cyclosporin beliefs regarding assigned treatment and clinical:... Shock, or chronic bronchitis also been studied for conditions other than depression long they last, which treatments available.
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